IEEE Spectrum Biomedical热榜

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IEEE Spectrum Biomedical

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01
How a Google DeepMind Spin-off Hunts Hidden Drug Targets
For more than a decade, artificial intelligence has been touted as a way to dramatically accelerate drug discovery . Yet despite billions of dollars in investment, relatively few AI-designed medicines have made it to patients. That’s partially because the timelines for careful drug testing can’t be easily compressed—and partially because drug development is just really hard. Isomorphic Labs , the Google DeepMind spin-off that’s building on DeepMind’s Nobel Prize-winning work on protein structureEliza Strickland
02
Ultrasound Patch Could Form Future Pacemaker
With the reliability of a quality wristwatch, pacemakers send out electric pulses to keep your heart beating at a steady rate. But unlike a watch, when the batteries need replacement, it’s a surgical affair—one that can be required as often as every five years . While the risks of having a pacemaker implanted are low, going under the knife always creates the potential for complications. A group of California and Massachusetts scientists have developed a pacemaker that works without requiring surAlex Music
03
Could This Blood-Filtering Device Help Treat Ebola?
As the deadly Bundibugyo strain of Ebola continues to ravage parts of Central Africa, physicians once again find themselves scrambling for ways to keep the sickest patients alive. Existing antibody treatments are strain-specific and don’t target the virus responsible for the current outbreak, leaving few therapies capable of clearing virus from the bloodstream. This forces doctors to rely largely on supportive care for people in advanced stages of disease. That treatment gap is reviving interestElie Dolgin
04
Poetry for Engineers: Cyborg Laboratory
This is the place where you face yourself, the you that could be you with a few different parts, a pump for your heart, eyes off color, and fresh off the shelf fake hair (a bit obvious), skin smoothed. You’re not perfect, but it’s a good start. Down to small digits, you’ll be improved. Memory maintained by small motors, as long as these gizmos don’t glitch. What’s before you? Full replacement or a constant game of test and switch, pieces peeled off, disconnected, removed, until you are not yoursPaul Jones
05
Leap in DNA Synthesis Slashes Time to Build New Genetic Sequences
A new method for writing DNA promises to unlock the potential of generative AI in biology, giving scientists a fast, affordable, and accurate way to physically build the novel genetic sequences that predictive models are now producing faster than anyone can construct them. The technique, called Sidewinder, can assemble dozens of genetic sequences simultaneously in a single test tube, producing just one incorrect junction for every 10 million assembly events—a level of precision that far surpasseElie Dolgin
06
System Boosts Speech Volume Based on Brain Signals
It can be difficult to carry on conversation in a crowded public setting, and even more so with any degree of hearing loss. But what if you could amplify only the person you wanted to hear and suppress the rest ? What if a computer could do that automatically by reading your brain? When we focus on a particular person talking, we subconsciously track the gradual modulations in speech volume, which vary from speaker to speaker. This characteristic pattern appears in the brain activity of the listGreg Uyeno
07
Developers: Get Your Medical Mobile App Verified By IEEE
Patients who use mobile applications to manage medical conditions including depression and chronic pain might assume the apps have been evaluated by regulatory agencies to be safe and effective. But that isn’t necessarily the case. Most of the more than 55,000 medical apps that claim to diagnose or treat a condition—or ones that provide clinical decision support, known as “therapeutic” apps—have never been assessed by any trusted neutral bodies or regulatory agencies to evaluate them for technicKathy Pretz
08
Can AI Chatbots Reason Like Doctors?
One of the earliest stated goals for computing in medicine was to aid in clinical reasoning: the decision-making steps required to reach a diagnosis and form a treatment plan. And over the years, researchers have built many clinical decision support systems, which have typically been purpose-built, with painstakingly written rules about symptoms, test thresholds, and medication interactions. As artificial intelligence capabilities develop, clinical reasoning is a natural application. Now, a largGreg Uyeno
09
Chatbots Need Guardrails to Prevent Delusions and Psychosis
Millions of people worldwide are turning to chatbots like ChatGPT or Claude, and a proliferating class of specialized AI companionship apps for friendship, therapy, or even romance. While some users report psychological benefits from these simulated relationships, research has also shown the relationships can reinforce or amplify delusions, particularly among users already vulnerable to psychosis. AIs have been linked to multiple suicides, including the death of a Florida teenager who had a montStephen Cousins
10
Bionic Tech Must Prove Itself Beyond the Lab
I first met Robert Woo in 2011, during his third time walking in a powered exoskeleton . The architect had been paralyzed in a construction accident four years earlier, but he was determined to get back on his feet. Watching him clunk across a rehab room in an exoskeleton prototype, the technology felt astonishing. I had the same reaction when reporting on early brain-computer interfaces (BCIs), which enabled paralyzed people to move robotic arms or communicate by thought alone . Both types of bEliza Strickland
11
Do We Really Need Smarter AI to Cure Cancer?
By some estimates, more than a trillion dollars have already been invested in artificial intelligence. But large tech companies , including Meta and OpenAI, are still not content with today’s AI; they say they’ve set their sights on powerful, versatile AI that by some measure would match or even exceed human performance. A remarkable amount of resources is being poured into developing artificial general intelligence (AGI) or even more capable artificial super intelligence (ASI). Excitement arounGreg Uyeno
12
Chips Sense Free Radicals With Speed
When things go bad—be it beer, batteries, or blood—they generate a certain class of molecules called free radicals. Scientists use a technique called electron paramagnetic resonance (EPR) spectroscopy to pick up the concentration and identities of free radicals, but today’s equipment relies on huge, heavy magnets. Groups of researchers in California, Germany, and now France have been inventing ways to shrink the whole spectroscopy system onto a chip, so scientists can take the instrument into thSamuel K. Moore
13
Can Biologists Rewrite the Genome’s Spaghetti Code?
What if biology stopped being something we study and started becoming something we design? That’s the premise of Adrian Woolfson ’s new book, On the Future of Species: Authoring Life by Means of Artificial Biological Intelligence , which published on 28 April from MIT Press . He argues that advances in AI and DNA synthesis are pushing biology toward an engineering paradigm—one in which scientists can generate new genetic sequences and eventually build organisms to order. He calls this emerging cEliza Strickland
14
Engineering Collisions: How NYU Is Remaking Health Research
This sponsored article is brought to you by NYU Tandon School of Engineering . The traditional approach to academic research goes something like this: Assemble experts from a discipline, put them in a building, and hope something useful emerges. Biology departments do biology. Engineering departments do engineering. Medical schools treat patients. NYU is turning that model inside out. At its new Institute for Engineering Health , the organizing principle centers around disease states rather thanThomas Machinchick
15
Contact Lens Uses Microfluidics to Monitor and Treat Glaucoma
More than 80 million people suffer from glaucoma globally , making it the second most common cause of blindness worldwide. The disease—caused by elevated internal eye pressure damaging the optic nerve—is incurable, but its progression can be slowed with drugs to control eye pressure. Now, researchers have developed an electronics-free smart contact lens that can track the disease in real time and also deliver drugs in response. The all-polymer lens includes a microfluidic sensor that monitors eyEdd Gent
16
What It’s Like to Live With an Experimental Brain Implant
Scott Imbrie vividly remembers the first time he used a robotic arm to shake someone’s hand and felt the robotic limb as if it were his own. “I still get goosebumps when I think about that initial contact,” he says. “It’s just unexplainable.” The moment came courtesy of a brain implant: an array of electrodes that let him control a robotic arm and receive tactile sensations back to the brain. Getting there took decades. In 1985, Imbrie had woken up in the hospital after a car accident with a broEdd Gent
17
Chip Can Project Video the Size of a Grain of Sand
By many estimates, quantum computers will need millions of qubits to realize their potential applications in cybersecurity, drug development, and other industries. The problem is, anyone who has wanted to simultaneously control millions of a certain kind of qubit has run into the problem of trying to control millions of laser beams. That’s exactly the challenge that was faced by scientists working on the MITRE Quantum Moonshot project , which brought together scientists from MITRE, MIT, the UnivVelvet Wu
18
Tiny Graphene Drums Let Doctors Identify Bacteria by Sound
Identifying bacteria by sight can be quite difficult. Why not listen to them instead? Researchers at TU Delft in the Netherlands and the university’s spinoff company SoundCell think that bacterial infections could be diagnosed with sound. They’ve crafted a nanoscale drum kit that uses some of the world’s smallest percussion instruments to turn a bacterium’s motions into song . Previously, the Delft researchers showed that listening to a germ’s drumbeat could quickly screen it for antibiotic resiRahul Rao
19
“Living Pharmacy” Implant Keeps Drug-Producing Cells Alive Longer
Cells that have been genetically engineered to produce drugs are a promising way to deliver medicines inside the human body, but keeping those cells alive is challenging. A new bioelectronic implant can now support populations of three different drug-producing cells for more than a month. The researchers behind the result say it’s a step toward “living pharmacies” that can deliver a range of drugs on demand. But another promising avenue involves using genetic engineering to turn cells into livinEdd Gent
20
Young Professional’s AI Tool Spots Mental Health Conditions
Abhishek Appaji has committed his career to bringing lifesaving technology to underresourced communities. The IEEE senior member weaves together artificial intelligence, biomedical engineering, deep learning, and neuroscience to make doctors’ jobs easier and to improve patient outcomes. “The intersection of these fields is where the most impactful breakthroughs in diagnostic precision occur,” says Appaji, an associate professor of medical electronics engineering at the B.M.S. College of EngineerAmanda Davis
21
Scientists Build Living Robots With Nervous Systems
Engineers have long tried to mimic life. They’ve built machine learning algorithms modeled after the human brain , designed machines that walk like dogs or fly like insects , and taught robots to adapt, however clumsily , to the world around them. Now they are skipping imitation altogether. Instead of taking inspiration from biology, they are building robots out of it: fashioning tiny, free-swimming assemblages of living cells that organize into self-directed systems, complete with neurons that Elie Dolgin
22
What Exoskeletons Learned From One Relentless User
It’s easy to assume that Robert Woo was defined by the accident that took away his ability to walk. Certainly, the day of his accident—14 December 2007—was a turning point. Woo, an architect working on the new Goldman Sachs headquarters in New York City, hadn’t attended his company’s holiday party the night before, and that morning he was the only one in the trailer that served as the construction-site office. He was bent over his laptop when, 30 floors above, a crane’s nylon sling gave way , seEliza Strickland
23
Can Electrical Stimulation Restore Sight?
The optic nerve is like a high-speed fiber-optic cable between your eyes and your brain. But once that cable is cut, whether through trauma or disease , the nerve cannot be repaired and vision cannot be restored. Some engineers are working to change that. Shadi Dayeh , a professor of electrical and computer engineering at UC San Diego, has been developing a technology that could electrically stimulate and regenerate the optic nerve. His work is part of a multidisciplinary initiative called VISIONovid Parsi
24
How Your Virtual Twin Could One Day Save Your Life
One morning in May 2019, a cardiac surgeon stepped into the operating room at Boston Children’s Hospital more prepared than ever before to perform a high-risk procedure to rebuild a child’s heart. The surgeon was experienced, but he had an additional advantage: He had already performed the procedure on this child dozens of times—virtually. He knew exactly what to do before the first cut was made. Even more important, he knew which strategies would provide the best possible outcome for the child Steve Levine
25
Lab-on-a-Chip Grippers Could Handle Human Cells
Living cells and tissues grown in the lab are vital tools for helping scientists learn about basic biology and test new drugs. Growing miniature organs on a chip from a person’s stem cells could even one day help doctors test personalized treatments . Now, researchers have developed a lab-on-a-chip that adds a new feature to these systems: low-power grippers that can hold cells or tiny organ models called organoids in place. The CMOS-compatible lab-on-a-chip features shape-memory grippers and chKatherine Bourzac
26
This RF Tag Is Lighter Than a Dewdrop
Scientists don’t know much about how insects spend their time, but it’s well worth finding out. Insects play key roles in food webs and pollinate our crops, and social insects have a lot to teach us about the basics of friendship formation and communication. An ultralightweight radio-frequency tag designed to be worn by a paper wasp may help scientists get a glimpse at some basic behavioral information that’s long been missing: Where do the animals go when they leave the nest? The tag is just 20Katherine Bourzac
27
The Millisecond That Could Change Cancer Treatment
Inside a cavernous hall at the Swiss-French border, the air hums with high voltage and possibility. From his perch on the wraparound observation deck, physicist Walter Wuensch surveys a multimillion-dollar array of accelerating cavities, klystrons, modulators, and pulse compressors—hardware being readied to drive a new generation of linear particle accelerators. Wuensch has spent decades working with these machines to crack the deepest mysteries of the universe. Now he and his colleagues are aimTom Clynes
28
“Cyborg” Tissue Could Help Fast-Track Cures for Type 1 Diabetes
Lab-grown cell therapies for diabetes are edging toward the clinic . Researchers can now coax stem cells to behave like pancreatic islets, the tiny clusters of cells that regulate blood sugar. But even the most promising candidate therapies still need months inside a patient’s body to fully mature and work reliably—and some never quite get there. Now researchers have found a way to watch—and even gently steer—that maturation in the lab. A team led by Harvard bioengineer Jia Liu and University ofElie Dolgin
29
Xiangyi Cheng Is Bringing AR to Classrooms and Hospitals
When Xiangyi Cheng published her first journal paper as a principal investigator in IEEE Access in 2024, it marked more than a professional milestone. For Cheng, an IEEE member and an assistant professor of mechanical engineering at Loyola Marymount University , in Los Angeles, it was the latest waypoint in a career shaped by curiosity, persistence, and a belief that technology should serve people—not the other way around. The paper’s title was “ Mobile Devices or Head-Mounted Displays: A ComparWillie D. Jones
30
Bond Strength, Biocompatibility, and Beyond
Designing a medical device? This whitepaper helps you evaluate adhesive options for biocompatibility, sterilization resistance, and manufacturability — so you can make the right material decision early. What Attendees will Learn How to select between epoxy, silicone, cyanoacrylate, and UV/LED curable adhesives based on your device requirements Which adhesive systems meet USP Class VI and ISO 10993-5 biocompatibility standards How different sterilization methods, such as autoclaving, EtO, gamma, Master Bond

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