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Frontiers · Neuroscience

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HISTORY近 30 天历史柱高表示当天去重热搜数量
202624273328302926303331200120022803250431052006
07/26—08/24 有历史数据
  • 01
    Mitochondrial–neuroimmune interfaces in post-stroke spasticity: from acute brain injury to chronic motor phenotypes
    Post-stroke spasticity is a common and clinically consequential manifestation of the upper motor neuron syndrome, yet its mechanisms are incompletely explained by stretch reflex hyperexcitability alone. Established models emphasize corticospinal and corticoreticulospinal injury, altered brainstem descending drive, spinal reflex amplification, impaired inhibitory control, and secondary changes in skeletal muscle and connective tissue. In parallel, stroke induces profound mitochondrial stress andZihang Huang
  • 02
    FIS1 dependent peripheral fission exacerbates mitochondrial fragmentation and dysfunction in prion diseases
    IntroductionMitochondrial dysfunction is an early and critical feature of neuronal injury in prion diseases, a group of fatal transmissible neurodegenerative disorders. Mitochondrial dynamics, a core component of mitochondrial quality control, maintains neuronal homeostasis through balanced fission and fusion. Although mitochondrial fission can be further divided into distinct spatial subtypes, the specific subtype involved in prion-associated neurotoxicity and its regulatory mechanisms remain uFengting Gou
  • 03
    Cellular senescence and senolytic therapy in traumatic brain injury
    Traumatic brain injury (TBI) is a major cause of death and long-term disability in the United States. The initial primary injury in TBI is followed by a secondary injury cascade of molecular events, which can persist for years, and contributes to neuroinflammation, neurodegeneration, and long-term functional deficits after TBI. In this review, we will discuss evidence that cellular senescence in TBI, where damaged cells enter a state of permanent cell-cycle arrest and release pro-inflammatory faDarrell W. Brann
  • 04
    Cerebrospinal fluid biomarkers in E200K genetic Creutzfeldt–Jakob disease: a national study from an endemic Slovak cohort
    BackgroundGenetic Creutzfeldt–Jakob disease (gCJD) is a rare inherited prion disorder caused by pathogenic variants in the PRNP gene. Slovakia represents one of the major endemic regions worldwide, with most genetic cases linked to the E200K variant. Reliable cerebrospinal fluid (CSF) biomarkers remain important for diagnosis and surveillance in this setting.MethodsWe analyzed CSF samples from 77 consecutive symptomatic patients with genetically confirmed E200K gCJD referred to the National RefeDana Zakova
  • 05
    Elevated cerebral blood flow in distal and intermediate arterial territories in pediatric sickle cell anemia
    IntroductionChildren with sickle cell anemia (SCA) are at increased risk of cerebrovascular complications due to chronic anemia and progressive vascular injury, yet how their cerebral hemodynamics are altered remains poorly understood. Previous research has shown that overall cerebral blood flow (CBF) is often higher in SCA, likely as an adaptive response to their chronic anemia, while this CBF increase is also linked to a greater risk of stroke, silent infarcts, and cognitive deficits. DistinguPing Zou Stinnett
  • 06
    Structural changes in gray matter and white matter across the Alzheimer’s disease continuum
    ObjectiveThe pathophysiological spectrum of Alzheimer’s disease (AD) is a continuum, with the AT(N) framework defining stages based on the presence of Aβ pathology, tau pathology, and neurodegeneration. However, the spatial characteristics of gray matter (GM) and white matter (WM) changes at different stages remain insufficiently defined. This study aimed to establish a cross-sectional cohort of the AD continuum using the AT(N) staging system and systematically delineate the spatial features ofShuai Lin
  • 07
    Age-associated differences in cervical sagittal alignment parameters among asymptomatic adults: a cross-sectional reference study
    PurposeWhile age-adjusted alignment goals are established for the lumbar spine, analogous clinically actionable tools are lacking for cervical sagittal assessment. This study aimed to derive and internally assess simple, age- and sex-specific formulas for key cervical parameters—thoracic inlet angle minus cervical lordosis (TIA-CL), neck tilt (NT), and cervical sagittal vertical axis (cSVA)—in asymptomatic adults.MethodsThis retrospective cross-sectional study analyzed 632 rigorously screened asYu Zhang
  • 08
    Correction: The impact of spatial normalization strategies on the temporal features of the resting-state functional MRI: spatial normalization before rs-fMRI features calculation may reduce the reliability
    Zhao Qing
  • 09
    A perspective on the use of the CatWalk device to assess dynamic spasticity in rodent models
    IntroductionSpasticity is a hallmark of upper motor neuron syndrome and arises from complex neurophysiological and biomechanical alterations, including disinhibition of the stretch reflex and secondary changes in muscle properties. While rodent models are widely used to study spasticity, objective assessment of dynamic spasticity during locomotion remains challenging. The CatWalk (CW) system is a well-established tool for automated gait analysis; however, its specific utility in quantifying spasJohannes C. Heinzel
  • 10
    Efficacy of transcranial direct current stimulation for disorders of consciousness: an updated systematic review and meta-analysis based on sham-controlled randomized trials
    BackgroundTranscranial direct current stimulation (tDCS) may improve behavioral signs of consciousness in patients with disorders of consciousness (DoC), but evidence from randomized controlled trials (RCTs) and previous meta-analyses has remained inconsistent. We evaluated the efficacy and safety of tDCS in patients with DoC and explored potential effect modifiers.MethodsPubMed, Embase, Scopus, Web of Science, and the Cochrane Library were searched for RCTs comparing active tDCS with sham stimuFuqiang Wang
  • 11
    Effects of acupuncture on mild cognitive impairment via the microbiota–gut–brain axis: a systematic review
    BackgroundMild Cognitive Impairment (MCI) is a critical window for intervention in neurodegenerative diseases. As emerging evidence suggests the role of microbiota–gut–brain (MGB) axis on cognitive health, this systematic review aims to evaluate the efficacy and underlying mechanisms of acupuncture in modulating the MGB axis to alleviate cognitive decline.MethodsA systematic search was conducted across PubMed/MEDLINE, Web of Science, Scopus, and Cochrane CENTRAL from inception to April 2026. FolMona Sadat Khalifeh Soltani
  • 12
    Graphomotor performance as a quantitative marker of Alzheimer’s disease: a tablet-based case–control ROC study
    BackgroundFrom the clinical and neurobiological perspective of cortico subcortical loop concepts, Alzheimer’s disease (AD) is associated with progressive deterioration of cognitive, emotional, and motor functions, which can be assessed subclinically using digital motion tracking technology in an electromagnetic digitizing tablet technology. Graphomotor analysis provides a source of sensitive digital biomarkers with potential applications in the early diagnosis and monitoring of AD.MethodsA case–Edward Jacek Gorzelańczyk
  • 13
    Localizing the epileptogenic zone in drug-resistant epilepsy based on ictal SEEG high-resolution time-frequency representation
    IntroductionDrug-resistant epilepsy (DRE) presents a critical clinical challenge, and accurate epileptogenic zone (EZ) localization is essential for successful surgical intervention. Stereoelectroencephalography (SEEG) is widely applied in clinical practice, but conventional visual inspection and high-frequency oscillations (HFOs) suffer from low efficiency, poor reproducibility, and insufficient representation of complex neural dynamics, failing to improve postsurgical seizure-free rates substaGenyu Fu
  • 14
    Electromyographic responses of the auriculomotor system during effortful listening in hearing aid users
    BackgroundAuricular muscles in humans may still display increased activity associated with auditory attention and effortful listening in complex patterns. As research into this auriculomotor system has primarily been conducted in normal-hearing participants, this study investigated electromyographic (EMG) signals of auricular muscles in hearing aid users under challenging listening conditions in order to evaluate their potential future use as a measure of perceived listening effort.MethodsTwentyAndreas Schroeer
  • 15
    Quantitative electroencephalography as a next-generation tool in neurodiagnostics: significance, clinical applications, and practical interpretative frameworks
    Introduction and objectiveThis article provides a comprehensive review of the methodology of Quantitative Electroencephalography (QEEG) as an advanced tool in modern neurodiagnostics. The objective of this study is to systematize knowledge regarding the technical aspects of signal acquisition, its specific clinical applications, and the interpretative frameworks that determine the efficacy of personalized therapeutic interventions in psychiatry and neurology.Materials and methodsThis paper constMarta Kopańska
  • 16
    A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque
    BackgroundThe fetal brain undergoes rapid cellular and structural changes in late gestation, when waves of neurogenesis and gliogenesis shape cortical circuitry. The ventricular zone (VZ), subventricular zone (SVZ), periventricular white matter (PVWM), and deep white matter (DWM) are enriched in neuroprogenitor cells, newborn neurons, and interneurons, which are regions challenging to study in the third-trimester human fetal brain. The nonhuman primate (NHP) provides a powerful translational modJohn A. Cornelius
  • 17
    Molecules, meaning, and physiology: disentangling the active ingredients of psychedelic therapeutics
    Psychedelic-assisted therapy has shown rapid and durable benefits across multiple psychiatric conditions, yet the mechanisms underlying these effects remain incompletely understood. Full-dose psychedelic sessions simultaneously engage serotonergic neurochemistry, high-intensity subjective experience, and autonomic-interoceptive physiology, making it difficult to determine which components are necessary or sufficient for therapeutic change. This perspective proposes that three partially separableKim P. C. Kuypers
  • 18
    A user-friendly graphical user interface for paw touch classification in rodent cylinder testing
    In unilateral rodent models of disease or injury, deficits are induced in only one side of the body, allowing the difference in right versus left limb usage to serve as a metric of disease/injury severity and recovery with various treatments. Unilateral rat models are commonly used for conditions such as Parkinson’s disease (via the neurotoxin 6-hydroxydopamine, 6-OHDA), stroke, and traumatic brain injury, as well as cervical spinal cord injury and peripheral nerve damage. The ‘cylinder test’ haTyler R. Johnson
  • 19
    Exploring the differences in neural oscillation mechanisms before and after sleep deprivation
    IntroductionSleep deprivation is widespread in modern society and can impair cognitive function and behavioral performance. However, the neural changes associated with individual differences in vulnerability to sleep loss remain unclear, particularly whether temporal fluctuations in neural oscillations provide information beyond conventional mean spectral measures.MethodsWe analyzed a publicly available resting-state electroencephalogram (EEG) dataset comprising 64 participants assessed under noZitong Cui
  • 20
    Reactive-accelerated-aging soak testing of thin-film polyimide layers treated with an oxygen plasma and chemical soaking
    Reliable bonding between polyimide layers is critical for the long-term performance of thin-film neural interfaces, yet the long-term durability of common adhesion methods under physiologically relevant conditions remains unclear. This study uses reactive-accelerated-aging (RAA) soak testing at 87°C to compare the ability of surface treatments based on oxygen plasma and KOH/HCl soaks to enhance polyimide-to-polyimide adhesion. Peel testing was performed as a function of soak time and strip widthKenneth A. Fluker