全部/知识/实时热榜

PubMed · 实时热榜

HISTORY2026年8月29日74 不同热搜
08/0309/01 有历史数据
DAILY UNIQUE TOPICS74 个热搜
  1. 01
    Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.

    趋势排名:7 · 期刊:Archives of general psychiatry · 类型:Randomized Controlled Trial · 语言:eng · PMID:15066900 · DOI:10.1001/archpsyc.61.4.412

    最高第 601:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  2. 02
    Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population.

    趋势排名:6 · 期刊:Diabetes research and clinical practice · 类型:Journal Article · 语言:eng · PMID:22515931 · DOI:10.1016/j.diabres.2012.03.012

    最高第 300:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  3. 03
    Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).

    趋势排名:9 · 期刊:Bioorganic & medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:26762835 · DOI:10.1016/j.bmc.2015.11.045 · PMC:PMC5947326

    最高第 916:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  4. 04
    Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.

    趋势排名:10 · 期刊:Bioorganic & medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:29523467 · DOI:10.1016/j.bmc.2018.02.022

    最高第 1016:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  5. 05
    NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.

    趋势排名:20 · 期刊:ChemMedChem · 类型:Journal Article · 语言:eng · PMID:29928781 · DOI:10.1002/cmdc.201800398

    最高第 2022:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  6. 06
    ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.

    趋势排名:37 · 期刊:European journal of medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:30384048 · DOI:10.1016/j.ejmech.2018.10.052 · PMC:PMC7115410

    最高第 3000:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  7. 07
    Discovery of 4H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models.

    趋势排名:8 · 期刊:Journal of medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:31693351 · DOI:10.1021/acs.jmedchem.9b01143

    最高第 816:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  8. 08
    Clinical outcomes and need for intensive care after non-ST-segment-elevation myocardial infarction.

    趋势排名:44 · 期刊:European journal of internal medicine · 类型:Journal Article · 语言:eng · PMID:32089424 · DOI:10.1016/j.ejim.2020.02.008

    最高第 3800:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  9. 09
    Electronic Health Record Integration of Predictive Analytics to Select High-Risk Stable Patients With Non-ST-Segment-Elevation Myocardial Infarction for Intensive Care Unit Admission.

    趋势排名:34 · 期刊:Circulation. Cardiovascular quality and outcomes · 类型:Journal Article · 语言:eng · PMID:33757310 · DOI:10.1161/CIRCOUTCOMES.120.007602

    最高第 3101:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  10. 10
    Objective monitoring tools for improved management of childhood asthma.

    趋势排名:3 · 期刊:Respiratory research · 类型:Review · 语言:eng · PMID:38702779 · DOI:10.1186/s12931-024-02817-y · PMC:PMC11069259

    最高第 200:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  11. 11
    Effect of Pre-Conditioning Temperature and Method of Curing on the Shear Bond Strength of Dual-Cure Composite Cements to Dentin.

    趋势排名:43 · 期刊:Materials (Basel, Switzerland) · 类型:Journal Article · 语言:eng · PMID:41753439 · DOI:10.3390/ma19040718 · PMC:PMC12942536

    最高第 3616:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  12. 12
    Prehospital epinephrine as a bridge to survival in traumatic cardiac arrest: A nationwide propensity score-matched analysis.

    趋势排名:5 · 期刊:The American journal of emergency medicine · 类型:Journal Article · 语言:eng · PMID:42372567 · DOI:10.1016/j.ajem.2026.06.039

    最高第 400:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  13. 13
    Postural Orthostatic Tachycardia Syndrome (POTS): A Review.

    趋势排名:15 · 期刊:JAMA · 类型:Journal Article · 语言:eng · PMID:42635998 · DOI:10.1001/jama.2026.14809

    最高第 700:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  14. 14
    Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome.

    趋势排名:45 · 期刊:JAMA internal medicine · 类型:Journal Article · 语言:eng · PMID:42636004 · DOI:10.1001/jamainternmed.2026.3983 · PMC:PMC13504484

    最高第 1500:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  15. 15
    DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.

    趋势排名:50 · 期刊:Cell · 类型:Journal Article · 语言:eng · PMID:42636811 · DOI:10.1016/j.cell.2026.07.041

    最高第 1700:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  16. 16
    Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.

    趋势排名:13 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42636832 · DOI:10.1016/S1470-2045(26)00278-0

    最高第 600:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  17. 17
    Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.

    趋势排名:32 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42636833 · DOI:10.1016/S1470-2045(26)00282-2

    最高第 1300:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  18. 18
    Childhood trauma and suicide ideation and attempts: Examining the mediating role of psychosocial, personality, lifestyle and biological factors.

    趋势排名:33 · 期刊:Journal of affective disorders · 类型:Journal Article · 语言:eng · PMID:42637149 · DOI:10.1016/j.jad.2026.122414

    最高第 1400:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  19. 19
    Association of Easier Biologic Access with Remission and Other Clinical Outcomes in Severe Asthma: A Global Real-World Study.

    趋势排名:26 · 期刊:Journal of asthma and allergy · 类型:Journal Article · 语言:eng · PMID:42638984 · DOI:10.2147/JAA.S597657 · PMC:PMC13501352

    最高第 2201:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  20. 20
    Intraosseous calvarial haematoma mimicking a skull tumour in a child with Noonan syndrome: a case report.

    趋势排名:1 · 期刊:Journal of surgical case reports · 类型:Journal Article · 语言:eng · PMID:42639270 · DOI:10.1093/jscr/rjag743 · PMC:PMC13502394

    最高第 100:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  21. 21
    IDSA/ACEP/ASM/PIDS/SCCM/SHEA/SHM/SIDP Multisociety Position Paper: Hospital Strategies to Improve Sepsis Outcomes.

    趋势排名:38 · 期刊:Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 类型:Journal Article · 语言:eng · PMID:42640090 · DOI:10.1093/cid/ciag438

    最高第 3501:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  22. 22
    Integrative spatial profiling of 3D genome organization and gene expression in tissue.

    趋势排名:35 · 期刊:Cell · 类型:Journal Article · 语言:eng · PMID:42641604 · DOI:10.1016/j.cell.2026.07.039 · PMC:PMC13509204

    最高第 3216:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  23. 23
    On-demand transarterial chemoembolisation combined with atezolizumab and bevacizumab in patients with untreated hepatocellular carcinoma (TALENTACE): a multicentre, randomised, open-label, phase 3 trial.

    趋势排名:12 · 期刊:The lancet. Gastroenterology & hepatology · 类型:Journal Article · 语言:eng · PMID:42641632 · DOI:10.1016/S2468-1253(26)00212-8

    最高第 1116:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  24. 24
    Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21.

    趋势排名:24 · 期刊:BMJ (Clinical research ed.) · 类型:Journal Article · 语言:eng · PMID:42642105 · DOI:10.1136/bmj-2026-100418

    最高第 2016:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  25. 25
    Toward unified and comprehensive automated electroencephalogram interpretation: a multicentre development and validation of an electroencephalogram foundation model.

    趋势排名:17 · 期刊:The Lancet. Digital health · 类型:Journal Article · 语言:eng · PMID:42642264 · DOI:10.1016/j.landig.2026.101039

    最高第 1610:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  26. 26
    Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.

    趋势排名:2 · 期刊:Nature aging · 类型:Journal Article · 语言:eng · PMID:42642518 · DOI:10.1038/s43587-026-01180-5

    最高第 222:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  27. 27
    A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.

    趋势排名:18 · 期刊:Nature aging · 类型:Journal Article · 语言:eng · PMID:42642521 · DOI:10.1038/s43587-026-01181-4

    最高第 1716:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  28. 28
    Oligodendrocyte dysfunction in human age-related cognitive decline.

    趋势排名:25 · 期刊:Nature medicine · 类型:Journal Article · 语言:eng · PMID:42642661 · DOI:10.1038/s41591-026-04608-y

    最高第 2419:12 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  29. 29
    Case Report: A rare case of multi-vessel coronary artery-coronary sinus fistula combined with multiple coronary aneurysms initially presenting with frequent premature ventricular complexes.

    趋势排名:27 · 期刊:Frontiers in cardiovascular medicine · 类型:Journal Article · 语言:eng · PMID:42643173 · DOI:10.3389/fcvm.2026.1920885 · PMC:PMC13503148

    最高第 2610:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  30. 30
    Neuroimaging Abnormalities and Genotype-Phenotype Correlations in Noonan Syndrome: A Multicenter Cohort Study.

    趋势排名:4 · 期刊:The Journal of clinical endocrinology and metabolism · 类型:Journal Article · 语言:eng · PMID:42657773 · DOI:10.1210/clinem/dgag352

    最高第 416:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分
  31. 31
    Effect of Workplace Violence on Turnover Intention: The Mediating Roles of Job Control, Psychological Demands, and Social Support.

    趋势排名:11 · 期刊:Inquiry : a journal of medical care organization, provision and financing · 类型:Journal Article · 语言:eng · PMID:33334214 · DOI:10.1177/0046958020969313 · PMC:PMC7750754

    最高第 1119:12 达到01:04 首次观测上榜当日结束时仍在榜累计约22小时40分
  32. 32
    Characteristics of Vaginal Microbiome in Reproductive-Age Females with HPV Infection in Xinjiang, China.

    趋势排名:14 · 期刊:Evidence-based complementary and alternative medicine : eCAM · 类型:Journal Article · 语言:eng · PMID:36387363 · DOI:10.1155/2022/7332628 · PMC:PMC9643059

    最高第 1416:16 达到01:04 首次观测上榜当日结束时仍在榜累计约22小时40分
  33. 33
    Generational IQ: Quasilongitudinal insights from the Wechsler Adult Intelligence Scale, Fifth Edition.

    趋势排名:39 · 期刊:Developmental psychology · 类型:Journal Article · 语言:eng · PMID:42329721 · DOI:10.1037/dev0002226

    最高第 3819:12 达到01:04 首次观测上榜当日结束时仍在榜累计约22小时40分
  34. 34
    Age-related differences in women's foot shape.

    趋势排名:50 · 期刊:Maturitas · 类型:Journal Article · 语言:eng · PMID:27823747 · DOI:10.1016/j.maturitas.2016.09.001

    最高第 1900:00 达到当日首次采集时已在榜22:08 观测离榜累计约22小时8分
  35. 35
    Global, regional, and national burden of HIV/AIDS, 1990-2023, with the estimated burden attributable to intimate partner violence and forecasted impacts of funding cuts through 2030: results from the Global Burden of Disease Study 2023.

    趋势排名:46 · 期刊:The lancet. HIV · 类型:Journal Article · 语言:eng · PMID:42612664 · DOI:10.1016/S2352-3018(26)00147-5

    最高第 1800:00 达到当日首次采集时已在榜22:08 观测离榜累计约22小时8分
  36. 36
    Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.

    趋势排名:23 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658930 · DOI:10.1126/science.aeb0054

    最高第 2319:12 达到04:16 首次观测上榜当日结束时仍在榜累计约19小时28分
  37. 37
    Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis.

    趋势排名:43 · 期刊:Leukemia · 类型:Journal Article · 语言:eng · PMID:42637879 · DOI:10.1038/s41375-026-03097-9

    最高第 4200:00 达到当日首次采集时已在榜19:12 观测离榜上榜 3 次(重入 2 次)累计约18小时40分
  38. 38
    Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.

    趋势排名:21 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658940 · DOI:10.1126/science.ady4523

    最高第 1605:36 达到05:36 首次观测上榜当日结束时仍在榜上榜 2 次(重入 1 次)累计约16小时48分
  39. 39
    Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.

    趋势排名:31 · 期刊:Frontiers in endocrinology · 类型:Systematic Review · 语言:eng · PMID:42643311 · DOI:10.3389/fendo.2026.1896180 · PMC:PMC13503531

    最高第 3119:12 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分
  40. 40
    2026 Guideline for Adult Stroke Rehabilitation and Recovery: A Guideline From the American Heart Association and American Stroke Association.

    趋势排名:16 · 期刊:Stroke · 类型:Review · 语言:eng · PMID:42657476 · DOI:10.1161/STR.0000000000000536

    最高第 1622:08 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分
  41. 41
    A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease.

    趋势排名:19 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658927 · DOI:10.1126/science.aeh7112

    最高第 1916:16 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分
  42. 42
    SGLT2 inhibitors activate pantothenate kinase in the human heart.

    趋势排名:22 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658934 · DOI:10.1126/science.aeh4856

    最高第 2019:12 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分
  43. 43
    Eating Alone as Social Disengagement is Strongly Associated With Depressive Symptoms in Japanese Community-Dwelling Older Adults.

    趋势排名:30 · 期刊:Journal of the American Medical Directors Association · 类型:Journal Article · 语言:eng · PMID:25687929 · DOI:10.1016/j.jamda.2015.01.078

    最高第 2500:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分
  44. 44
    Baveno VIII - Advancing Consensus in Portal Hypertension.

    趋势排名:43 · 期刊:Journal of hepatology · 类型:Review · 语言:eng · PMID:42624290 · DOI:10.1016/j.jhep.2026.07.030

    最高第 3200:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分
  45. 45
    Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.

    趋势排名:39 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42633754 · DOI:10.1016/S1470-2045(26)00228-7

    最高第 2900:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分
  46. 46
    An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction.

    趋势排名:25 · 期刊:Neuron · 类型:Journal Article · 语言:eng · PMID:42636812 · DOI:10.1016/j.neuron.2026.07.030

    最高第 2000:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分
  47. 47
    Sustained benefit of adjuvant olaparib in women with germline BRCA1- and BRCA2- -associated high-risk HER2-negative early breast cancer: Updated results from the OlympiA phase III trial.

    趋势排名:31 · 期刊:Annals of oncology : official journal of the European Society for Medical Oncology · 类型:Journal Article · 语言:eng · PMID:42636977 · DOI:10.1016/j.annonc.2026.08.002

    最高第 2600:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分
  48. 48
    ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.

    趋势排名:28 · 期刊:Bioorganic & medicinal chemistry letters · 类型:Journal Article · 语言:eng · PMID:30082069 · DOI:10.1016/j.bmcl.2018.06.040

    最高第 2816:16 达到10:08 首次观测上榜当日结束时仍在榜累计约13小时36分
  49. 49
    Immunometabolic endotypes define distinct clinical trajectories in type 2 diabetes.

    趋势排名:47 · 期刊:Cell metabolism · 类型:Journal Article · 语言:eng · PMID:42641605 · DOI:10.1016/j.cmet.2026.07.027

    最高第 4116:16 达到10:08 首次观测上榜当日结束时仍在榜累计约13小时36分
  50. 50
    Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness.

    趋势排名:30 · 期刊:JAMA psychiatry · 类型:Journal Article · 语言:eng · PMID:42647034 · DOI:10.1001/jamapsychiatry.2026.2574

    最高第 3022:08 达到10:08 首次观测上榜当日结束时仍在榜累计约13小时36分