
PubMed · 实时热榜
- 01Intraosseous calvarial haematoma mimicking a skull tumour in a child with Noonan syndrome: a case report.
趋势排名:1 · 期刊:Journal of surgical case reports · 类型:Journal Article · 语言:eng · PMID:42639270 · DOI:10.1093/jscr/rjag743 · PMC:PMC13502394
最高第 1 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 02Objective monitoring tools for improved management of childhood asthma.
趋势排名:3 · 期刊:Respiratory research · 类型:Review · 语言:eng · PMID:38702779 · DOI:10.1186/s12931-024-02817-y · PMC:PMC11069259
最高第 2 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 03Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.
趋势排名:2 · 期刊:Nature aging · 类型:Journal Article · 语言:eng · PMID:42642518 · DOI:10.1038/s43587-026-01180-5
最高第 2 名22:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 04Association of the PPARG Pro12Ala polymorphism with type 2 diabetes and incident coronary heart disease in a Hong Kong Chinese population.
趋势排名:6 · 期刊:Diabetes research and clinical practice · 类型:Journal Article · 语言:eng · PMID:22515931 · DOI:10.1016/j.diabres.2012.03.012
最高第 3 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 05Prehospital epinephrine as a bridge to survival in traumatic cardiac arrest: A nationwide propensity score-matched analysis.
趋势排名:5 · 期刊:The American journal of emergency medicine · 类型:Journal Article · 语言:eng · PMID:42372567 · DOI:10.1016/j.ajem.2026.06.039
最高第 4 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 06Neuroimaging Abnormalities and Genotype-Phenotype Correlations in Noonan Syndrome: A Multicenter Cohort Study.
趋势排名:4 · 期刊:The Journal of clinical endocrinology and metabolism · 类型:Journal Article · 语言:eng · PMID:42657773 · DOI:10.1210/clinem/dgag352
最高第 4 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 07Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.
趋势排名:7 · 期刊:Archives of general psychiatry · 类型:Randomized Controlled Trial · 语言:eng · PMID:15066900 · DOI:10.1001/archpsyc.61.4.412
最高第 6 名01:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 08Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study.
趋势排名:13 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42636832 · DOI:10.1016/S1470-2045(26)00278-0
最高第 6 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 09Postural Orthostatic Tachycardia Syndrome (POTS): A Review.
趋势排名:15 · 期刊:JAMA · 类型:Journal Article · 语言:eng · PMID:42635998 · DOI:10.1001/jama.2026.14809
最高第 7 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 10Discovery of 4H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models.
趋势排名:8 · 期刊:Journal of medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:31693351 · DOI:10.1021/acs.jmedchem.9b01143
最高第 8 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 11Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
趋势排名:9 · 期刊:Bioorganic & medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:26762835 · DOI:10.1016/j.bmc.2015.11.045 · PMC:PMC5947326
最高第 9 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 12Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
趋势排名:10 · 期刊:Bioorganic & medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:29523467 · DOI:10.1016/j.bmc.2018.02.022
最高第 10 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 13Effect of Workplace Violence on Turnover Intention: The Mediating Roles of Job Control, Psychological Demands, and Social Support.
趋势排名:11 · 期刊:Inquiry : a journal of medical care organization, provision and financing · 类型:Journal Article · 语言:eng · PMID:33334214 · DOI:10.1177/0046958020969313 · PMC:PMC7750754
最高第 11 名19:12 达到01:04 首次观测上榜当日结束时仍在榜累计约22小时40分 - 14On-demand transarterial chemoembolisation combined with atezolizumab and bevacizumab in patients with untreated hepatocellular carcinoma (TALENTACE): a multicentre, randomised, open-label, phase 3 trial.
趋势排名:12 · 期刊:The lancet. Gastroenterology & hepatology · 类型:Journal Article · 语言:eng · PMID:42641632 · DOI:10.1016/S2468-1253(26)00212-8
最高第 11 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 15Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.
趋势排名:32 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42636833 · DOI:10.1016/S1470-2045(26)00282-2
最高第 13 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 16Characteristics of Vaginal Microbiome in Reproductive-Age Females with HPV Infection in Xinjiang, China.
趋势排名:14 · 期刊:Evidence-based complementary and alternative medicine : eCAM · 类型:Journal Article · 语言:eng · PMID:36387363 · DOI:10.1155/2022/7332628 · PMC:PMC9643059
最高第 14 名16:16 达到01:04 首次观测上榜当日结束时仍在榜累计约22小时40分 - 17Childhood trauma and suicide ideation and attempts: Examining the mediating role of psychosocial, personality, lifestyle and biological factors.
趋势排名:33 · 期刊:Journal of affective disorders · 类型:Journal Article · 语言:eng · PMID:42637149 · DOI:10.1016/j.jad.2026.122414
最高第 14 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 18Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome.
趋势排名:45 · 期刊:JAMA internal medicine · 类型:Journal Article · 语言:eng · PMID:42636004 · DOI:10.1001/jamainternmed.2026.3983 · PMC:PMC13504484
最高第 15 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 19Toward unified and comprehensive automated electroencephalogram interpretation: a multicentre development and validation of an electroencephalogram foundation model.
趋势排名:17 · 期刊:The Lancet. Digital health · 类型:Journal Article · 语言:eng · PMID:42642264 · DOI:10.1016/j.landig.2026.101039
最高第 16 名10:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 202026 Guideline for Adult Stroke Rehabilitation and Recovery: A Guideline From the American Heart Association and American Stroke Association.
趋势排名:16 · 期刊:Stroke · 类型:Review · 语言:eng · PMID:42657476 · DOI:10.1161/STR.0000000000000536
最高第 16 名22:08 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分 - 21Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology.
趋势排名:21 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658940 · DOI:10.1126/science.ady4523
最高第 16 名05:36 达到05:36 首次观测上榜当日结束时仍在榜上榜 2 次(重入 1 次)累计约16小时48分 - 22DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.
趋势排名:50 · 期刊:Cell · 类型:Journal Article · 语言:eng · PMID:42636811 · DOI:10.1016/j.cell.2026.07.041
最高第 17 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 23A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.
趋势排名:18 · 期刊:Nature aging · 类型:Journal Article · 语言:eng · PMID:42642521 · DOI:10.1038/s43587-026-01181-4
最高第 17 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 24Global, regional, and national burden of HIV/AIDS, 1990-2023, with the estimated burden attributable to intimate partner violence and forecasted impacts of funding cuts through 2030: results from the Global Burden of Disease Study 2023.
趋势排名:46 · 期刊:The lancet. HIV · 类型:Journal Article · 语言:eng · PMID:42612664 · DOI:10.1016/S2352-3018(26)00147-5
最高第 18 名00:00 达到当日首次采集时已在榜22:08 观测离榜累计约22小时8分 - 25Age-related differences in women's foot shape.
趋势排名:50 · 期刊:Maturitas · 类型:Journal Article · 语言:eng · PMID:27823747 · DOI:10.1016/j.maturitas.2016.09.001
最高第 19 名00:00 达到当日首次采集时已在榜22:08 观测离榜累计约22小时8分 - 26A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease.
趋势排名:19 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658927 · DOI:10.1126/science.aeh7112
最高第 19 名16:16 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分 - 27NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
趋势排名:20 · 期刊:ChemMedChem · 类型:Journal Article · 语言:eng · PMID:29928781 · DOI:10.1002/cmdc.201800398
最高第 20 名22:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 28An inherited hypomorphic variant in PIEZO2 reveals structural features of mechanotransduction.
趋势排名:25 · 期刊:Neuron · 类型:Journal Article · 语言:eng · PMID:42636812 · DOI:10.1016/j.neuron.2026.07.030
最高第 20 名00:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分 - 29Prevalence of chronic traumatic encephalopathy at death in National Football League players: retrospective population based cohort study, 2008-21.
趋势排名:24 · 期刊:BMJ (Clinical research ed.) · 类型:Journal Article · 语言:eng · PMID:42642105 · DOI:10.1136/bmj-2026-100418
最高第 20 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 30SGLT2 inhibitors activate pantothenate kinase in the human heart.
趋势排名:22 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658934 · DOI:10.1126/science.aeh4856
最高第 20 名19:12 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分 - 31TDP-43-Associated Neurodegenerative Disease Conceptualization and Integrated Staging: A Review.
趋势排名:27 · 期刊:JAMA neurology · 类型:Journal Article · 语言:eng · PMID:42636000 · DOI:10.1001/jamaneurol.2026.2812
最高第 22 名00:00 达到当日首次采集时已在榜10:08 观测离榜累计约10小时8分 - 32Association of Easier Biologic Access with Remission and Other Clinical Outcomes in Severe Asthma: A Global Real-World Study.
趋势排名:26 · 期刊:Journal of asthma and allergy · 类型:Journal Article · 语言:eng · PMID:42638984 · DOI:10.2147/JAA.S597657 · PMC:PMC13501352
最高第 22 名01:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 33Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.
趋势排名:23 · 期刊:Science (New York, N.Y.) · 类型:Journal Article · 语言:eng · PMID:42658930 · DOI:10.1126/science.aeb0054
最高第 23 名19:12 达到04:16 首次观测上榜当日结束时仍在榜累计约19小时28分 - 34Enzymatic activity-independent NANS stabilizes LATS2 to drive growth and therapeutic resistance in HR+/HER2- breast cancer.
趋势排名:25 · 期刊:Nature communications · 类型:Journal Article · 语言:eng · PMID:42642385 · DOI:10.1038/s41467-026-75386-x · PMC:PMC13507113
最高第 24 名05:20 达到05:20 首次观测上榜05:52 观测离榜累计约32分钟 - 35Oligodendrocyte dysfunction in human age-related cognitive decline.
趋势排名:25 · 期刊:Nature medicine · 类型:Journal Article · 语言:eng · PMID:42642661 · DOI:10.1038/s41591-026-04608-y
最高第 24 名19:12 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 36Eating Alone as Social Disengagement is Strongly Associated With Depressive Symptoms in Japanese Community-Dwelling Older Adults.
趋势排名:30 · 期刊:Journal of the American Medical Directors Association · 类型:Journal Article · 语言:eng · PMID:25687929 · DOI:10.1016/j.jamda.2015.01.078
最高第 25 名00:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分 - 37Sustained benefit of adjuvant olaparib in women with germline BRCA1- and BRCA2- -associated high-risk HER2-negative early breast cancer: Updated results from the OlympiA phase III trial.
趋势排名:31 · 期刊:Annals of oncology : official journal of the European Society for Medical Oncology · 类型:Journal Article · 语言:eng · PMID:42636977 · DOI:10.1016/j.annonc.2026.08.002
最高第 26 名00:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分 - 38Case Report: A rare case of multi-vessel coronary artery-coronary sinus fistula combined with multiple coronary aneurysms initially presenting with frequent premature ventricular complexes.
趋势排名:27 · 期刊:Frontiers in cardiovascular medicine · 类型:Journal Article · 语言:eng · PMID:42643173 · DOI:10.3389/fcvm.2026.1920885 · PMC:PMC13503148
最高第 26 名10:08 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 39ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
趋势排名:28 · 期刊:Bioorganic & medicinal chemistry letters · 类型:Journal Article · 语言:eng · PMID:30082069 · DOI:10.1016/j.bmcl.2018.06.040
最高第 28 名16:16 达到10:08 首次观测上榜当日结束时仍在榜累计约13小时36分 - 40ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups.
趋势排名:29 · 期刊:Bioorganic & medicinal chemistry letters · 类型:Journal Article · 语言:eng · PMID:29945794 · DOI:10.1016/j.bmcl.2018.06.043
最高第 29 名22:08 达到22:08 首次观测上榜当日结束时仍在榜累计约1小时36分 - 41Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.
趋势排名:39 · 期刊:The Lancet. Oncology · 类型:Randomized Controlled Trial · 语言:eng · PMID:42633754 · DOI:10.1016/S1470-2045(26)00228-7
最高第 29 名00:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分 - 42ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells.
趋势排名:37 · 期刊:European journal of medicinal chemistry · 类型:Journal Article · 语言:eng · PMID:30384048 · DOI:10.1016/j.ejmech.2018.10.052 · PMC:PMC7115410
最高第 30 名00:00 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 43Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness.
趋势排名:30 · 期刊:JAMA psychiatry · 类型:Journal Article · 语言:eng · PMID:42647034 · DOI:10.1001/jamapsychiatry.2026.2574
最高第 30 名22:08 达到10:08 首次观测上榜当日结束时仍在榜累计约13小时36分 - 44Electronic Health Record Integration of Predictive Analytics to Select High-Risk Stable Patients With Non-ST-Segment-Elevation Myocardial Infarction for Intensive Care Unit Admission.
趋势排名:34 · 期刊:Circulation. Cardiovascular quality and outcomes · 类型:Journal Article · 语言:eng · PMID:33757310 · DOI:10.1161/CIRCOUTCOMES.120.007602
最高第 31 名01:04 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 45Changes in vascular structure and function in primary hyperparathyroidism: a systematic review and meta-analysis.
趋势排名:31 · 期刊:Frontiers in endocrinology · 类型:Systematic Review · 语言:eng · PMID:42643311 · DOI:10.3389/fendo.2026.1896180 · PMC:PMC13503531
最高第 31 名19:12 达到07:12 首次观测上榜当日结束时仍在榜累计约16小时32分 - 46Baveno VIII - Advancing Consensus in Portal Hypertension.
趋势排名:43 · 期刊:Journal of hepatology · 类型:Review · 语言:eng · PMID:42624290 · DOI:10.1016/j.jhep.2026.07.030
最高第 32 名00:00 达到当日首次采集时已在榜16:16 观测离榜累计约16小时16分 - 47Integrative spatial profiling of 3D genome organization and gene expression in tissue.
趋势排名:35 · 期刊:Cell · 类型:Journal Article · 语言:eng · PMID:42641604 · DOI:10.1016/j.cell.2026.07.039 · PMC:PMC13509204
最高第 32 名16:16 达到当日首次采集时已在榜当日结束时仍在榜累计约23小时44分 - 48Anti-CD45RB monoclonal antibody-mediated transplantation tolerance.
趋势排名:39 · 期刊:Current molecular medicine · 类型:Review · 语言:eng · PMID:11899229 · DOI:10.2174/1566524013363348
最高第 33 名00:00 达到当日首次采集时已在榜10:08 观测离榜累计约10小时8分 - 49Cryo-EM structures of biopsy-derived TTR fibrils in hereditary transthyretin amyloidosis.
趋势排名:33 · 期刊:Nature communications · 类型:Journal Article · 语言:eng · PMID:42642419 · DOI:10.1038/s41467-026-75850-8 · PMC:PMC13507274
最高第 33 名10:24 达到10:24 首次观测上榜10:40 观测离榜累计约16分钟 - 50Elacestrant in Combination with Everolimus for Estrogen Receptor-Positive, HER2-Negative Previously Treated Advanced Breast Cancer: Results from ELEVATE.
趋势排名:38 · 期刊:Clinical cancer research : an official journal of the American Association for Cancer Research · 类型:Journal Article · 语言:eng · PMID:42635598 · DOI:10.1158/1078-0432.CCR-26-1816
最高第 34 名00:00 达到当日首次采集时已在榜04:16 观测离榜累计约4小时16分



































