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01
Animal Crossing and COVID-19: A Qualitative Study Examining How Video Games Satisfy Basic Psychological Needs During the Pandemic.
趋势排名：1 · 期刊：Frontiers in psychology · 类型：Journal Article · 语言：eng · PMID：35465561 · DOI：10.3389/fpsyg.2022.800683 · PMC：PMC9022176Yee AZH, Sng JRH
02
Fatalities from venomous and nonvenomous animals in the United States (1999-2007).
趋势排名：2 · 期刊：Wilderness & environmental medicine · 类型：Journal Article · 语言：eng · PMID：22656661 · DOI：10.1016/j.wem.2012.02.012Forrester JA, Holstege CP, Forrester JD
03
Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease.
趋势排名：3 · 期刊：The New England journal of medicine · 类型：Randomized Controlled Trial · 语言：eng · PMID：42456136 · DOI：10.1056/NEJMoa2517588Tian J, Wang Z, Wang Y et al.
04
Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones.
趋势排名：4 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457955 · DOI：10.1038/s41586-026-10779-yShay JES, Chi F, Tzouanas CN et al.
05
Colorectal anastomotic safety assessment using ICG fluorescence and flexible endoscopy (COLOSSEUM): a global survey of 1367 surgeons.
趋势排名：5 · 期刊：Surgical endoscopy · 类型：Journal Article · 语言：eng · PMID：42443689 · DOI：10.1007/s00464-026-12974-4Belvedere A, Licardie E, Sochorova D et al.
06
GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma.
趋势排名：6 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457964 · DOI：10.1038/s41586-026-10786-zZhang Q, Fu Q, Shen Y et al.
07
An early chondrichthyan and the evolutionary assembly of a shark body plan.
趋势排名：7 · 期刊：Proceedings. Biological sciences · 类型：Journal Article · 语言：eng · PMID：29298937 · DOI：10.1098/rspb.2017.2418 · PMC：PMC5784200Coates MI, Finarelli JA, Sansom IJ et al.
08
Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.
趋势排名：8 · 期刊：JAMA · 类型：Journal Article · 语言：eng · PMID：42449500 · DOI：10.1001/jama.2026.12556 · PMC：PMC13370474Buckley RF, Townsend DL, Birkenbihl CJ et al.
09
CD4(+) T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis.
趋势排名：9 · 期刊：Science translational medicine · 类型：Journal Article · 语言：eng · PMID：42455903 · DOI：10.1126/scitranslmed.adz6566 · PMC：PMC13374717Bjornevik K, Mahler JV, Bilodeau PA et al.
10
Dendritic cells control tertiary lymphoid structure development and maintenance in cancer.
趋势排名：10 · 期刊：Science (New York, N.Y.) · 类型：Journal Article · 语言：eng · PMID：42462020 · DOI：10.1126/science.ady1678Mattiuz R, Boumelha J, Aerakis E et al.
11
Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma.
趋势排名：11 · 期刊：The New England journal of medicine · 类型：Randomized Controlled Trial · 语言：eng · PMID：42456135 · DOI：10.1056/NEJMoa2600157 · PMC：PMC13374710Kumar S, Jacobus S, Cohen A et al.
12
[Podiatric risk screening in patients with type 2 diabetes in Antananarivo].
趋势排名：12 · 期刊：The Pan African medical journal · 类型：Journal Article · 语言：fre · PMID：28979615 · DOI：10.11604/pamj.2017.27.213.11311 · PMC：PMC5622827Raharinavalona SA, Ramalanjaona HR, Andrianera N et al.
13
Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study.
趋势排名：13 · 期刊：Psychiatry research · 类型：Journal Article · 语言：eng · PMID：28214781 · DOI：10.1016/j.psychres.2017.02.027Feingold D, Rehm J, Lev-Ran S
14
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts.
趋势排名：14 · 期刊：Cancer discovery · 类型：Journal Article · 语言：eng · PMID：42458705 · DOI：10.1158/2159-8290.CD-25-2245Haldar SD, Huff AL, Wang HH et al.
15
Switching to camizestrant at ESR1 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6): extended analysis of a double-blind, placebo-controlled, randomised, phase 3 trial.
趋势排名：15 · 期刊：The Lancet. Oncology · 类型：Journal Article · 语言：eng · PMID：42442380 · DOI：10.1016/S1470-2045(26)00287-1Turner NC, Mayer EL, Park YH et al.
16
Transforming Pulmonary Arterial Hypertension: Key Milestones and Future Perspectives.
趋势排名：16 · 期刊：Circulation · 类型：Review · 语言：eng · PMID：42441757 · DOI：10.1161/CIRCULATIONAHA.126.079274Humbert M, Zeder K, Kovacs G et al.
17
Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.
趋势排名：17 · 期刊：CA: a cancer journal for clinicians · 类型：Journal Article · 语言：eng · PMID：42417444 · DOI：10.3322/caac.70090 · PMC：PMC13343830Sung H, Filho AM, Laversanne M et al.
18
Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging.
趋势排名：18 · 期刊：Science (New York, N.Y.) · 类型：Journal Article · 语言：eng · PMID：42462036 · DOI：10.1126/science.aea3075Tan YJ, Conley TE, Yao F et al.
19
Multidomain lifestyle intervention for the prevention of cognitive decline in at-risk older adults in Latin America (LatAm-FINGERS): a single-blind, multicentre, randomised controlled trial.
趋势排名：19 · 期刊：Lancet (London, England) · 类型：Journal Article · 语言：eng · PMID：42442374 · DOI：10.1016/S0140-6736(26)01278-XCrivelli L, Suemoto CK, Sosa AL et al.
20
Ebbs and Flows of Desire: A Qualitative Exploration of Contextual Factors Affecting Sexual Desire in Bisexual, Lesbian, and Straight Women.
趋势排名：20 · 期刊：Journal of sex & marital therapy · 类型：Journal Article · 语言：eng · PMID：33026308 · DOI：10.1080/0092623X.2020.1828207Vowels LM, Rosenkrantz DE, Brown HM et al.
21
Efficacy and safety of dabrafenib plus trametinib in adults with differentiated thyroid cancer: a randomised, double-blind, placebo-controlled, phase 3 trial.
趋势排名：21 · 期刊：The Lancet. Oncology · 类型：Journal Article · 语言：eng · PMID：42442381 · DOI：10.1016/S1470-2045(26)00133-6Gao M, Park YJ, Lin CC et al.
22
An encyclopedia of human enhancer-gene regulatory interactions.
趋势排名：22 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457959 · DOI：10.1038/s41586-026-10781-4Gschwind AR, Mualim KS, Karbalayghareh A et al.
23
[Psychiatric adverse effects in hemodialysis patients with chronic kidney disease: a clinical dimension with prognostic implications].
趋势排名：23 · 期刊：Vertex (Buenos Aires, Argentina) · 类型：Journal Article · 语言：spa · PMID：42446301Hernández Navas JA, Gelvez Mantilla J, Hernández Navas V
24
Fibromyalgia.
趋势排名：24 · 期刊：The New England journal of medicine · 类型：Review · 语言：eng · PMID：42456138 · DOI：10.1056/NEJMcp2411656Williams DA, Clauw DJ
25
Metabolic Syndrome among Secondary School Teachers: Exploring the Ignored Dimension of School Health Programme.
趋势排名：25 · 期刊：Journal of clinical and diagnostic research : JCDR · 类型：Journal Article · 语言：eng · PMID：27190836 · DOI：10.7860/JCDR/2016/14868.7631 · PMC：PMC4866134Narayanappa S, Manjunath R, Kulkarni P
26
Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.
趋势排名：26 · 期刊：Nature medicine · 类型：Journal Article · 语言：eng · PMID：42458007 · DOI：10.1038/s41591-026-04491-7Chen W, Jiang L, Duan C et al.
27
Structure and evolution-guided design of minimal RNA-guided nucleases.
趋势排名：27 · 期刊：Science (New York, N.Y.) · 类型：Journal Article · 语言：eng · PMID：42462008 · DOI：10.1126/science.aed6123Skopintsev P, Esain-Garcia I, DeTurk EC et al.
28
Acute exacerbation in fibrotic interstitial lung disease: An International Working Group Report.
趋势排名：28 · 期刊：American journal of respiratory and critical care medicine · 类型：Journal Article · 语言：eng · PMID：42447235 · DOI：10.1093/ajrccm/aamag363Khor YH, Luppi F, Adegunsoye A et al.
29
A spliceosome-independent eukaryote generated by complete intron removal.
趋势排名：29 · 期刊：Cell · 类型：Journal Article · 语言：eng · PMID：42456655 · DOI：10.1016/j.cell.2026.05.033Man X, Zhang WT, Zhang YD et al.
30
Destination Is an Intervention: Why SOF Medics Must Own Capability-Based Evacuation Planning.
趋势排名：30 · 期刊：Journal of special operations medicine : a peer reviewed journal for SOF medical professionals · 类型：Editorial · 语言：eng · PMID：42447463 · DOI：10.55460/J.Spec.Oper.Med.2026.MRLR-9F19Baines EM, Kretz E, Remley MA et al.
31
Men and women's waking patterns to infant crying: Preparenthood differences are insufficient to explain uneven sharing of nighttime care.
趋势排名：31 · 期刊：Emotion (Washington, D.C.) · 类型：Journal Article · 语言：eng · PMID：39819066 · DOI：10.1037/emo0001478Vermillet AQ, Skewes JC, Parsons CE
32
Astrocytic lipid dysregulation as an early driver of neurodegeneration.
趋势排名：32 · 期刊：Nature reviews. Neurology · 类型：Review · 语言：eng · PMID：42443387 · DOI：10.1038/s41582-026-01238-3Kim WS, Halliday GM
33
Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
趋势排名：33 · 期刊：JAMA · 类型：Journal Article · 语言：eng · PMID：42441390 · DOI：10.1001/jama.2026.13116 · PMC：PMC13366243Blazhenets G, Soleimani-Meigooni DN, Chiotis K et al.
34
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
趋势排名：34 · 期刊：Nature genetics · 类型：Meta-Analysis · 语言：eng · PMID：23817569 · DOI：10.1038/ng.2686 · PMC：PMC3753407Hinds DA, McMahon G, Kiefer AK et al.
35
Micro- and nano-plastics in the coronary circulation and air pollution exposure in ischaemic heart disease presentation.
趋势排名：35 · 期刊：European heart journal · 类型：Journal Article · 语言：eng · PMID：42447841 · DOI：10.1093/eurheartj/ehag447Paolisso P, Scisciola L, Belmonte M et al.
36
Interleukin 6 Receptor Blockade for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
趋势排名：36 · 期刊：JAMA neurology · 类型：Journal Article · 语言：eng · PMID：42440328 · DOI：10.1001/jamaneurol.2026.2220 · PMC：PMC13366257Vilaseca A, Bilodeau PA, Gakis G et al.
37
Modular in vivo antibody-ADC click to reverse drug resistance in tumours.
趋势排名：37 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457957 · DOI：10.1038/s41586-026-10789-wSimó C, Vanover AC, D'Oliveira Albanus R et al.
38
Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus.
趋势排名：38 · 期刊：Nature reviews. Gastroenterology & hepatology · 类型：Review · 语言：eng · PMID：42463525 · DOI：10.1038/s41575-026-01224-6Petrov MS, Yamazaki H, Lu G et al.
39
Long-Term Ravulizumab Efficacy and Safety in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder: Final CHAMPION-NMOSD Results.
趋势排名：39 · 期刊：Neurology(R) neuroimmunology & neuroinflammation · 类型：Randomized Controlled Trial · 语言：eng · PMID：42441931 · DOI：10.1212/NXI.0000000000200609 · PMC：PMC13372128Pittock SJ, Barnett MH, Bennett JL et al.
40
Allogeneic CD70-Targeted Chimeric Antigen Receptor T-Cell Therapy for Advanced Renal Cell Carcinoma: Results From the Phase I TRAVERSE Trial.
趋势排名：40 · 期刊：Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 类型：Journal Article · 语言：eng · PMID：42447427 · DOI：10.1200/JCO-26-00388Srour SA, Chahoud J, Drakaki A et al.
41
Modifiable Risk Factors and Attributable Ischemic Heart Disease Mortality in US States, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023.
趋势排名：41 · 期刊：JAMA cardiology · 类型：Journal Article · 语言：eng · PMID：42455550 · DOI：10.1001/jamacardio.2026.2435 · PMC：PMC13373740Benziger CP, Stark B, Johnson CO et al.
42
A queen odour mediates reproductive suppression in a eusocial mammal.
趋势排名：42 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457958 · DOI：10.1038/s41586-026-10772-5Khallaf MA, Hart DW, Luo W et al.
43
Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.
趋势排名：43 · 期刊：The Lancet. Neurology · 类型：Journal Article · 语言：eng · PMID：42456684 · DOI：10.1016/S1474-4422(26)00198-5Lange LM, Fang ZH, Makarious MB et al.
44
Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification.
趋势排名：44 · 期刊：Nature communications · 类型：Journal Article · 语言：eng · PMID：42449117 · DOI：10.1038/s41467-026-75357-2 · PMC：PMC13369989Berghaus N, Tauziède-Espariat A, Hielscher T et al.
45
Type 2 Diabetes in Morocco: Toward a Precision Diabetology, from Pathogenesis to Treatment.
趋势排名：45 · 期刊：Annals of African medicine · 类型：Journal Article · 语言：eng, fre · PMID：40699993 · DOI：10.4103/aam.aam_87_25 · PMC：PMC13056275Guerboub AA, Issouani J, Lakssir I et al.
46
Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity.
趋势排名：46 · 期刊：Immunity · 类型：Journal Article · 语言：eng · PMID：42442359 · DOI：10.1016/j.immuni.2026.06.010Wang Y, Shen Y, Liu J et al.
47
YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial.
趋势排名：47 · 期刊：JAMA · 类型：Journal Article · 语言：eng · PMID：42437322 · DOI：10.1001/jama.2026.10676 · PMC：PMC13358875Akerboom B, Martens ESL, Stals MAM et al.
48
Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank.
趋势排名：48 · 期刊：Diabetes care · 类型：Journal Article · 语言：eng · PMID：42439362 · DOI：10.2337/dc26-0797Guan Z, Stephan BCM, Siervo M
49
An anti-PMEL antibody-drug conjugate with a G(q/1)(1) inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.
趋势排名：49 · 期刊：Nature medicine · 类型：Journal Article · 语言：eng · PMID：42443515 · DOI：10.1038/s41591-026-04518-zCarlino MS, Kapiteijn E, Piperno-Neumann S et al.
50
Cell-type signatures of Alzheimer's disease shared across population groups.
趋势排名：50 · 期刊：Nature · 类型：Journal Article · 语言：eng · PMID：42457956 · DOI：10.1038/s41586-026-10793-0Luquez T, Algoo J, Chiu R et al.