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实时热搜

7分钟前更新
  • 0120
    Resonance
    排名:1 · Test and explore web services · 分类:development · 近 30 天安装:2,164 · 趋势分:20.00 · 许可:MIT · 开发者已验证Dennis Blümer
  • 0220
    Era
    排名:2 · Manage your time · 分类:utility · 近 30 天安装:1,643 · 趋势分:20.00 · 许可:GPL-3.0-or-later · 开发者已验证Titouan Real
  • 0320
    Trilium Notes
    排名:3 · Build your personal knowledge base · 分类:office · 近 30 天安装:3,861 · 趋势分:20.00 · 许可:AGPL-3.0-only · 开发者已验证Trilium Notes Team
  • 0420
    Railway
    排名:4 · Find all your travel information · 分类:utility · 近 30 天安装:2,901 · 趋势分:19.97 · 许可:GPL-3.0-or-later · 开发者已验证Julian Schmidhuber
  • 0520
    2009scape
    排名:5 · 2009 Runescape Emulation · 分类:game · 近 30 天安装:1,659 · 趋势分:19.96 · 许可:AGPL-3.0-or-later · 开发者已验证2009scape
  • 0620
    Text Pieces
    排名:6 · Developer's scratchpad · 分类:utility · 近 30 天安装:2,491 · 趋势分:19.94 · 许可:GPL-3.0-or-later · 开发者已验证Gleb Smirnov
  • 0720
    Spider
    排名:7 · Install web apps · 分类:network · 近 30 天安装:1,808 · 趋势分:19.89 · 许可:GPL-3.0-only · 开发者已验证Zaedus
  • 0820
    Space Cadet Pinball
    排名:8 · Game engine for Space Cadet Pinball · 分类:game · 近 30 天安装:11,756 · 趋势分:19.78 · 许可:MITAndrey Muzychenko
  • 0920
    zelda3
    排名:9 · Zelda3 is a reverse engineered clone of Zelda - A Link to the Past · 分类:game · 近 30 天安装:544 · 趋势分:19.52 · 许可:MITsnesrev
  • 1019
    Curo Calculator
    排名:10 · Financial calculations simplified · 分类:office · 近 30 天安装:655 · 趋势分:19.03 · 许可:LicenseRef-proprietary · 开发者已验证Andrew Murphy
  • 1118
    gMTP
    排名:11 · A simple multimedia manager for MTP-based Digital Audio Players · 分类:audiovideo · 近 30 天安装:361 · 趋势分:17.94 · 许可:BSD-3-Clause · 开发者已验证Roman Yepishev
  • 1216
    Authenticator
    排名:12 · Generate two-factor codes · 分类:utility · 近 30 天安装:4,740 · 趋势分:16.49 · 许可:GPL-3.0-or-later · 开发者已验证Bilal Elmoussaoui
  • 1316
    Inscriptions
    排名:13 · Translate text elegantly · 分类:office · 近 30 天安装:763 · 趋势分:15.86 · 许可:GPL-3.0-or-later · 开发者已验证Stella and Charlie!
  • 1415
    Pix
    排名:14 · Image Gallery · 分类:graphics · 近 30 天安装:1,510 · 趋势分:15.23 · 许可:LGPL-3.0 · 开发者已验证maui
  • 1515
    Chromium Web Browser
    排名:15 · The web browser from Chromium project · 分类:network · 近 30 天安装:44,281 · 趋势分:15.20 · 许可:BSD-3-Clause and LGPL-2.1+ and Apache-2.0 and IJG and MIT and GPL-2.0+ and ISC and OpenSSL and (MPL-1.1 or GPL-2.0 or LGPL-2.0)The Chromium Authors
  • 1615
    Raspberry Pi Imager
    排名:16 · Raspberry Pi Imaging utility · 分类:utility · 近 30 天安装:4,176 · 趋势分:15.06 · 许可:Apache-2.0Raspberry Pi Ltd
  • 1715
    Color My Desktop
    排名:17 · Personalize your desktop with custom generated themes using colors you choose · 分类:system · 近 30 天安装:927 · 趋势分:14.95 · 许可:Apache-2.0 AND MIT · 开发者已验证Schwarzen
  • 1815
    Defuse
    排名:18 · Remove image backgrounds locally · 分类:utility · 近 30 天安装:1,828 · 趋势分:14.86 · 许可:GPL-3.0-or-later · 开发者已验证Shone Binu
  • 1914
    BMI Calculator
    排名:19 · Calculate your BMI · 分类:utility · 近 30 天安装:745 · 趋势分:13.58 · 许可:GPL-3.0-or-later · 开发者已验证Johannes Böhler
  • 2013
    CloudCompare
    排名:20 · 3D point cloud and mesh processing · 分类:graphics · 近 30 天安装:2,422 · 趋势分:13.09 · 许可:GPL-3.0 · 开发者已验证EDF R&D / TELECOM ParisTech (ENST-TSI)
15分钟前更新
  • 01
    Loss of microbial diversity from human–microbe coevolution: immune, epigenetic, and enteric nervous system mechanisms linking dysbiosis to neuropsychiatric and neurodegenerative diseases
    Homo sapiens are the only species of humans still existing, as far as we know. Sapiens became the “sensible, shrewd, knowing” species of humanoids (the Homo genus) with assistance from the gut microbiota that evolved alongside and within Homo sapiens, providing metabolites and assisting the gut-brain axis to aid brain expansion and function. This review discusses coevolution, how dietary and environmental changes have influenced the importance of the gut microbiota, the microbiome-gut-brain axisHajar Heidari
  • 02
    Tensor decomposition reveals discrete cortical reorganization under graded propofol anesthesia
    BackgroundAlthough propofol-induced anesthesia is known to suppress consciousness by promoting low-frequency frontal oscillations through thalamocortical circuits, a comprehensive understanding of its whole-brain coupling feature set remains elusive. Specifically, the global reorganization of nonlinear cross-frequency coupling remains poorly characterized due to analytical limitations.MethodsWe analyzed 64-channel EEG data from 17 participants across five states (awake and target propofol concenChuan-Di Tong
  • 03
    Longitudinal changes in resting-state EEG eyes-closed/open delta differentiation during an Antarctic expedition
    Antarctic polar night brings extreme light deprivation, prolonged isolation and severe circadian disruption, yet longitudinal resting-state electroencephalography (EEG) signatures reflecting neurophysiological alterations in this harsh environment remain poorly characterized. In this exploratory longitudinal research, resting-state EEG recordings with eyes open (EO) and eyes closed (EC) were acquired from 16 Antarctic expeditioners at four mission stages: pre-departure, pre-polar-night, early poWeiting Yang
  • 04
    Longitudinal white matter network reorganization after rTMS in first-episode schizophrenia: associations with sleep improvement
    BackgroundSleep disturbances are highly prevalent in first-episode schizophrenia and are associated with poor clinical and functional outcomes. Although repetitive transcranial magnetic stimulation (rTMS) has shown therapeutic potential for insomnia and schizophrenia, its efficacy for sleep disturbances in first-episode schizophrenia remains insufficiently characterized, and the underlying white matter network mechanisms remain unclear. This study aimed to determine whether active rTMS improvesYan Li
  • 05
    Insulin resistance–related metabolic burden, white matter microstructure, and cognitive change: the HABS-HD study
    BackgroundInsulin resistance–related metabolic burden is associated with cognitive aging, but the relevant white matter microstructural features remain unclear. We examined statistical indirect associations between metabolic indices and cognition through tract-level white matter measures, including associations with subsequent cognitive change.MethodsCross-sectional and longitudinal analyses used Health and Aging Brain Study–Health Disparities (HABS-HD) data. Exposures were the triglyceride–glucHuaiyi Li
  • 06
    SMBO: a Sinusoidal Modulation Bi-population Optimizer for brain cancer MRI image clustering
    This study proposes the Sinusoidal Modulation Bi-population Optimizer (SMBO), which couples a sinusoidal modulation of the step size, jointly driven by iteration progress and individual fitness quality, with dynamic behavior switching (DBS) to achieve a self-adaptive, threshold-free balance between exploration and exploitation. This balance is further reinforced by an asymmetric information flow (AIF) mechanism that sustains diversity between the elite and exploration sub-populations. In simulatYingzhi Li
  • 07
    Neuroimmune phenotypes in brain aneurysms and neurodegenerative diseases
    Aneurysmal subarachnoid hemorrhage is a devastating neurological disease that occurs downstream of abnormal dilation of cerebral vessels and weakening of the vessel wall due to underlying inflammation. Vascular endothelial inflammation has been identified as a critical driver of aneurysm growth and progression, with numerous immune cell populations proposed to have a role in this process. The innate immune cells that partake in the process of aneurysm growth, primarily macrophages, can adopt proFrancis J. Lauzier
  • 08
    Functional magnetic resonance imaging in neuropathic pain: a bibliometric analysis incorporating machine learning
    BackgroundNeuropathic pain (NP) affects 6.9%–10% of the global population. Functional magnetic resonance imaging (fMRI) has become central to NP investigation, yet few studies have systematically mapped this literature. We used bibliometric and machine-learning methods to chart the fMRI-NP research landscape.MethodsWe retrieved 1,866 fMRI-NP articles (2005–2025) from Web of Science, PubMed, and Scopus. Following PRISMA guidelines, we analyzed publication trends, citation metrics, and collaboratiNing Sun
  • 09
    Case Report: Right frontal periventricular heterotopia underlying secondary network epilepsy with a Lennox–Gastaut phenotype: multimodal SEEG, CCEP, and rs-fMRI evidence
    ObjectiveLennox–Gastaut syndrome (LGS) is generally regarded as a developmental and epileptic encephalopathy involving distributed brain networks, although a focal structural abnormality may occasionally recruit bilateral cortical and thalamic circuits and produce an LGS phenotype. We characterized the spatiotemporal organization of such a network and its changes after focal SEEG-guided radiofrequency thermocoagulation (RF-TC).MethodsA 50-year-old woman with drug-resistant epilepsy, multiple seiChangquan Wang
  • 10
    Complementary white matter networks support flexible concept learning
    IntroductionConcept learning is not an isolated act of cognition; it recruits a host of core mechanisms, including working memory, decision making, and attention. A wide range of brain networks spanning cortical and subcortical areas support these operations, which have been identified via activation patterns related to concept learning. A critical open question, however, is whether the white matter architecture connecting these regions serves as the structural scaffold that makes such flexibleMelisa Gumus
  • 11
    Effects of individualized phase-amplitude-coupled transcranial alternating current stimulation on tinnitus and cognition
    IntroductionChronic tinnitus is a prevalent and disabling condition that is frequently accompanied by domain-specific cognitive difficulties. Abnormal neural oscillations and disrupted cross-frequency coupling (CFC) have been implicated in its pathophysiology. This study investigated whether individualized phase-amplitude-coupled transcranial alternating current stimulation (tACS), tailored to each participant’s individual alpha frequency (IAF), was associated with changes in tinnitus symptoms,Youngmin Na
  • 12
    Decoding user satisfaction during reading of pre-defined question–answer pairs: BCI approach using delta and gamma EEG
    IntroductionThe rapid proliferation of large language models (LLMs) has intensified the need for robust evaluation frameworks to align artificial intelligence (AI) behavior with human expectations. While current reinforcement learning from human feedback (RLHF) strategies heavily rely on explicit, post-hoc self-reports, these metrics are fundamentally limited by subjective biases and user non-compliance.MethodsTo address this, the current study presents a novel brain-computer interface (BCI) fraWanjoo Park
  • 13
    Classical and intermediate monocytes and their ratios in the natural immune course of ischemic stroke
    IntroductionMonocytes contribute to the immune response to ischemic stroke (IS), participating in both acute inflammation and post-ischemic repair. However, classical (cMo), intermediate (intMo), and non-classical (ncMo) monocytes differ in function, and composite indices such as the lymphocyte-to-monocyte ratio (LMR) do not distinguish between them. We characterized the dynamics of monocyte subpopulations and of two subset-derived ratios, the lymphocyte-to-classical monocyte ratio (LMRclas) andMarta Oses
  • 14
    Spatial robustness of P100 latency compared with amplitude: a data-driven rationale for visual pathway monitoring during neuroendovascular procedures
    Intraoperative visual evoked potential (VEP) monitoring has a reputation for being unreliable, and much of that belongs to P100 amplitude. Amplitude shifts with electrode position, anesthetic depth, and dipole geometry. Practice has nonetheless tended to lean on amplitude, and to treat latency as the weaker of the two. Neuroendovascular procedures give reason to shift that emphasis. During open surgery there can be a mixture of direct and ischemic neural injury, whereas in an endovascular procedSu Ji Lee
  • 15
    Clinical spectrum and genotype–phenotype correlations of MT-CYB-associated mitochondrial disease: from the m.15045G > A variant to the broader disease landscape
    AimTo characterize the clinical and molecular features associated with the MT-CYB m.15045G > A variant and investigate the clinical spectrum and genotype–phenotype relationships of MT-CYB-associated mitochondrial disease.MethodsWe performed comprehensive clinical, metabolic, histopathological, genetic, and mitochondrial functional analyses in a patient carrying the m.15045G > A variant. A systematic literature review of previously reported disease-associated MT-CYB variants was conducted, followZimeng He
  • 16
    Dynamic EEG network responses to acupuncture stimulation in patients with stroke: a neurophysiological study
    ObjectiveAcupuncture may modulate brain activity through effects on the central nervous system. This study aimed to investigate short-term changes in spontaneous EEG activity and functional connectivity during acupuncture in patients with stroke using multichannel electroencephalography (EEG).MethodsMultichannel EEG recordings were collected at three stages: before acupuncture, during acupuncture, and after acupuncture. Acupuncture was applied at Jianyu, Quchi, and Waiguan. EEG activity was evalJianxin Tan
  • 17
    Towards a nonlinear “neuroimmune gate-model”: beyond stellate ganglion block and vagus nerve stimulation
    We propose a three-level neuroimmune gate model to characterize the communication between the nervous system and the immune system. The first gate, Gate 1, is the peripheral neuroimmune gate. Here, immune cells, inflammatory mediators, sensory neurons, autonomic nervous system neurons, blood vessels, and specific tissue components interact. The second gate, Gate 2, is the spinal neuroimmune gate and includes spinal afferents, spinal neurons and circuits, preganglionic sympathetic neurons, and miLorenz Fischer
  • 18
    Connectomes: a re-emerging hub dataset for neuroscience
    Connectomics aims to generate complete neural wiring diagrams and leverage them to explain brain function at a systems level. Traditional neuroscience has relied on sparse recordings and partial circuit reconstructions, limiting mechanistic insight into how distributed neural activity produces behavior. By contrast, connectomes provide comprehensive maps of all neurons and all synapses, analogous in some respects to the transformative impact of whole-genome sequencing in biology. Early efforts,Sebastian Kyllmann
  • 19
    Influence of a full-spectrum aqueous extract of black cardamom (Amomum subulatum Roxb.) fruits on focus/alertness and executive function: a randomized, double-blind, placebo-and active- controlled, 14-day comparative study in healthy working professionals
    BackgroundNootropics enhance cognitive functions, including memory, attention, alertness, mood, and reaction time, through diverse neurobiological mechanisms. Caffeine, one of the most widely consumed nootropics, improves cognitive performance primarily by promoting wakefulness and alertness; however, these effects are generally transient. Consequently, there is growing interest in plant-derived, food-grade nootropics that can provide sustained cognitive benefits with a favorable safety profile.Jestin V. Thomas
  • 20
    A pilot study of invasive vagus nerve stimulation in Chinese patients with Alzheimer’s disease: preliminary results on safety, cognition, and biomarkers
    IntroductionAlzheimer’s disease (AD) is a progressive neurodegenerative disorder with no curative therapies, and vagus nerve stimulation (VNS) has emerged as a promising neuromodulatory approach. This prospective, open-label pilot study aimed to evaluate the feasibility, safety, and preliminary cognitive, psychological, inflammatory, and AD biomarker effects of invasive VNS (iVNS) in Chinese AD patients.MethodsFive AD patients (mean age: 62.4 ± 4.0 years) underwent iVNS implantation, with assessYingchuan Chen
6小时前更新
  • 01
    TidGi(太记) v0.14.2
    TTidGi 是一个基于「太微 TiddlyWiki」的知识管理桌面应用,能够保护隐私内容、高级自动化、自动Git云备份、部署为博客,并且可以通过RESTAPI与Anki等应用连接...
  • 02
    SwitchHosts(主机管理工具) v5.0.2
    SwitchHosts 是一个功能强大、用户友好的工具,专门用于管理和切换多个 hosts 方案。它为用户提供了方便的界面和操作方式,使得在不同网络环境下实现域名解析的灵活切换变得...
  • 03
    Knowledge Base(知识库应用) v1.64.0
    Knowledge Base 是一款本地优先的知识库桌面应用。核心功能包括所见即所得的 Markdown 编辑、双向链接、知识图谱可视化、基于 SQLite FTS5 的全文搜索、...
  • 04
    GTweak(系统优化工具) v5.5.5 绿色版
    GTweak 是一个 Windows 10/11 系统优化与“精简/隐私加固”工具箱,用来关掉大量默认服务、遥测、预装应用,并调整界面和电源等设置。 软件特色 关闭/卸载微软服务和...
  • 05
    FocusAny(AI工具条) v2.2.0
    ‌FocusAny‌是一个专注高效的AI工具条,可以通过Alt / Option+空格一键唤起,并通过插件快速安装,扩展出多种功能。 软件特色 剪切板管理‌:内置的剪切板管理功能可...
  • 06
    ContextMenuMgrPlus(右键菜单工具) v1.7.6 便携版
    Context Menu Manager Plus 是一个强大的实用程序,它可帮助您管理 Windows 上的右键菜单,并避免第三方向你的右键菜单里塞屎。 软件特色 管理传统右键菜...
  • 07
    AutoGLM(智谱AI输入法) v1.11.6
    智谱AI输入法(AutoGLM)是智谱AI推出的一款桌面端智能输入工具,基于GLM-ASR语音识别模型和AutoGLM智能体能力。 软件特色 语音转文字:支持实时中文语音转文字,自...
  • 08
    Android 碎碎记(IdeaMemo) v3.1.1
    IdeaMemo 是一款 Android 轻量级以标签 Tag 为核心的卡片便签App。功能上类似于日记或备忘录,但更强调碎片化和快速记录。它的设计理念偏向简洁,直观,用户可以随时...
  • 09
    Android GoRead(电子阅读器) v1.5.7
    GoRead 是一款专为本地电子书阅读打造的轻量级阅读器应用,支持桌面与移动端(Android / iOS),让你在多设备上都能获得统一、流畅的阅读体验。GoRead 聚焦「本地电...
  • 10
    Android FeedMe(RSS阅读器) v4.11.2
    FeedMe 是一款RSS阅读器,它能够从8大RSS阅读器中读取RSS内容并用来阅读,包括 Feedly、InoReader、The Older Reader、Tiny Tiny ...
  • 11
    青简输入法 v0.1.4
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  • 05
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  • 07
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  • 08
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  • 10
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  • 11
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